Risk factors for carbapenem-resistant Klebsiella pneumoniae infection in elderly hospitalized patients and analysis of its resistance gene types
Objective To explore the risk factors for infection with carbapenem-resistant Klebsiella pneumoniae (CRKP) in hospitalized elderly patients and to analyze the resistance gene types of CRKP.Methods A total of 178 hospitalized elderly patients infectied with Klebsiella pneumoniae (KPN) from January 2021 to December 2023 in Wuying County of Zhejiang Province were included in this study.Patients were divided into the carbapenem-sensitive Klebsiella pneumoniae (CSKP) group and the CRKP group based on their susceptibility to carbapenem-class antibiotics.The risk factors for CRKP infection were analyzed,and the resistance gene types of CRKP strains were detected using the colloidal gold method.Results Among 178 patients,61 were infected with CRKP accounting for 30.34％,the highest rate was in ICU patients (27.78％);CRKP were isolated most from sputum samples (40.74％),followed from urine samples (24.07％).The resistance rates of CRKP to tigecycline,amikacin and tobramycin were relatively low.Univariate and binary multivariate logistic regression analyses identified use of carbapenem-class antibiotics,cephalosporins and broad-spectrum penicillins,diabetes,urinary catheterization,and mechanical ventilation as independent risk factors for CRKP infection in elderly hospitalized patients (all P<0.05).The resistance gene type detection showed that the major carbapenemase resistance phenotypes were Klebsiella pneumoniae carbapenemase (70.37％) and New Delhi metallo-β-lactamase (16.67％).Conclusion CRKP in elderly hospitalized patients exhibits high resistance to conventional antibiotics,and attention should be paid to related risk factors of CRKP infection for this goup of patients.
万方数据
维普
