Expression of DDIAS in colorectal cancer and its clinicopathological significance
Objective To investigate the expression of DNA damage-induced apoptosis suppressor (DDIAS) in colorec-tal cancer and its clinicopathological significance.Methods The clinical and pathological data of 176 patients with colorectal cancer who received surgical treatment at the First People's Hospital of Fuyang Hangzhou from January 2018 to December 2020 were retrospectively analyzed.The expression of DDIAS was detected by immunohistochemical staining (EnVision method) in tumor tissues and corresponding pericancerous tissues,and the relationship between DDIAS expression and clinicopathological features of colorectal cancer was analyzed.Results The positivity rate of DDIAS in tumor tissues was significantly higher than that in pericancerous tissues (89.8％ vs.44.9％,P<0.001).The positivity rate of DDIAS in patients with T1-3 stage was significantly lower than that in patients with T4 (85.1％ vs.94.4％,P<0.05).There was no significant difference in the DDIAS positivity rate among patients with different age,gender,tumor differentiation,lymph node metastasis status,tumor location,histology type,mismatch repair protein expression,and Ki-67 index (all P>0.05).Conclusion DDIAS is highly expressed in colorectal cancer and is associated with tumor T stages.
万方数据
维普
