Relationship between serum mannose-binding lectin levels and repture risk of unreptured intracranial aneurysm
Objective To investigate the relationship of serum mannose-binding lectin (MBL) levels with rupture risk of unreptured intracranial aneurysms (UIAs).Methods One hundred and twenty patients with UIAs admitted to Wenzhou Central Hospital from June 2020 to December 2022 were enrolled.According to Predicting Hemorrhagic Aneurysm Symptoms and Events scores,patients were categorized into low-risk group (n=58),moderate-risk group (n=32),and high-risk group (n=30).Serum MBL levels were measured,and digital subtraction angiography parameters were calculated.Univariate analysis and multiple linear regression analysis were employed to investigate the factors related to the rupture risk of intracranial aneurysm.Results There were no significant differences in gender,age,smoking and alcohol history,history of hypertension and diabetes,previous subarachnoid hemorrhage,aneurysm location,and the presence of multiple aneurysms among three groups (all P>0.05);while the serum MBL level,aneurysm size,size ratio,aspect ratio,and irregular aneurysm morphology in three groups were significant different (all P<0.05).Multiple linear regression analysis indicated that higher serum MBL level (β=7.567,95％CI:6.804-8.331,P<0.001)and higher size ratio (β=0.534,95％CI:0.260-0.809,P<0.001) were independent influencing factors for aneurysm rupture.Conclusion Patients with UIAs at high risk of repture have higher levels of serum MBL,which is an indepent risk factor for aneurysm repture.Detecting MBL may become a new means of assessing the risk of aneurysm repture.
Mannose-binding lectinAneurysm rupture riskSize ratio
万方数据
维普
