Pineal Regulation of the"Heart Corresponding to Summer"Theory of Seasonal Rhythm Changes in Rats Based on ANP,BNP and NT-proBNP Levels in Myocardial Tissue
[Objective]To investigate the biological basis of the theory of"heart corresponding to summer"by observing the differences in the secretion of atrial natriuretic peptide(ANP),brain natriuretic peptide(BNP)and amino-terminal pro-B-type natriuretic peptide(NT-proBNP)in the myocardial tissues of the rats at the summer solstice and the winter solstice.[Methods]Specific pathogen free grade male SD rats were randomly divided into 4 groups,which were treated as normal control group,chronic heart failure(CHF)group,pineal gland removal group and composite model(CHF+pineal gland removal)group,and the contents of ANP,BNP and NT-proBNP were detected in myocardial tissues of the rats in each group at the winter solstice and summer solstice time points.[Results]Under normal physiological conditions,the secretion of ANP,BNP and NT-proBNP in rat myocardial tissues showed seasonal rhythmic changes of low in summer and high in winter;after the removal of the pineal gland,the seasonal rhythmic differences of ANP,BNP and NT-proBNP disappeared,and even appeared to be inverted;under the condition of CHF,the secretion of ANP,BNP and NT-proBNP in rat myocardial tissues showed seasonal rhythmic changes of high in summer and low in winter,and the original rhythm disappeared after the removal of the pineal gland.[Conclusion]Myocardial tissue ANP,BNP,NT-proBNP is the important biological material basis of the"heart corresponding to summer",their secretion of summer and winter seasonal rhythm changes,and the pathological state of CHF show the opposite of the normal state of the seasonal rhythm.At the same time,the pineal gland is involved in the seasonal regulation of the heart corresponding to summer.
heart corresponding to summerchronic heart failurepineal glandANPBNPNT-proBNP
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