In order to understand the drug resistance of Nocardia seriolae from hybrid snakehead in the Pearl River Delta region of Guangdong Province,the research group conducted an epidemiological survey of hybrid snakehead from March 2021 to July 2022.A total of 127 strains of pathogenic bacteria were iso-lated from hybrid snakehead,including 42 strains of N.seriolae.The drug resistance of 27 strains of N.seriolae was analyzed.The results showed that N.seriolae could be isolated throughout the year,account-ing for 33.1％of all isolated strains.The majority of N.seriolae strains were sensitive or resistant to the same drug,e.g.completely resistant to β-lactams(100％),and sensitive to macrolides(85.2％).Some strains in Foshan area were more resistant than those in Zhongshan area,and all the strains were multi-drug resistant.The overall drug resistance spectrum of N.seriolae was similar,and the multi-drug resistance was serious.There were some differences in the drug resistance of some strains in Foshan and Zhongshan areas.This study provides a reference for the precise medication of hybrid snakehead nocardiosis.
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