Application of CRISPR/Cas9 genome editing system in research and therapy of cancer
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NETL
NSTL
维普
万方数据
规律成簇间隔短回文重复(clustered regularly interspaced short palindromic repeat,CRISPR)/CRISPR相关蛋白核酸酶9(CRISPR-associated nuclease 9,Cas9)基因编辑技术是新涌现的一种基因编辑技术,它能精准完成RNA导向的DNA识别及编辑,为构建更高效的基因编辑技术提供了可能,目前科研人员已经可以实现在碱基水平对基因进行定点修饰.CRISPR/Cas9基因编辑技术已经被广泛应用于肿瘤研究中.本文对CRISPR/Cas9基因编辑技术在基因编辑中的分子机制及其在临床治疗和肿瘤研究中应用的研究进展进行综述.
Clustered regulatory interspaced short palindromic repeat (CRISPR)/ CRISPR-associated 9 (Cas9) genome editing system is a new tool that is able to edit the cellular genome guided by RNA to recognize and edit DNA,providing the possibility to more efficient gene editing,which enables researchers to precisely manipulate specific genomic elements at the base level.Moreover,CRISPR/Cas9 genome editing system has been widely used in cancer research.This review summarizes the molecular mechanism of the CRISPR/Cas9 genome editing system,and introduces its application in cancer research and potential therapy in clinical practice based on the latest research.
NETL
NSTL
维普
万方数据
