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食管癌围手术期治疗现状和思考

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多年来,中国食管癌围手术期治疗都是以化疗或放化疗为主.近年来,随着以免疫检查点抑制剂为代表的免疫治疗、多学科综合治疗、分子病理指导下的精准治疗以及不同肿瘤负荷表型(T/N负荷相对关系)指导下的导向性选择等不同疗法的涌现,食管癌围手术期治疗的传统模式受到了挑战,但这也为重新审视当前食管癌围手术期治疗模式提供了新机遇,并且将有助于促进食管癌围手术期治疗策略的优化.因此,研究者需要对食管癌围手术期治疗的现状充分了解并进行进一步思考.
Current situation and thinking of perioperative treatment of esophageal cancer
For many years,the perioperative treatment of esophageal cancer in China has been based on chemotherapy or chemoradiotherapy.However,in the recent years,with the emergence of immunotherapy represented by immune checkpoint inhibitors,multidisciplinary comprehensive treatment,precise treatment under the guidance of molecular pathology,and guided selection of different therapies under the guidance of different tumor load phenotypes(T/N load relative relationship),the traditional model of perioperative treatment of esophageal cancer is faced with challenges.Nonetheless,it has also provided new opportunities to re-examine the current perioperative treatment model of esophageal cancer,which will also help to promote the optimization of perioperative treatment strategies for esophageal cancer.Therefore,it is necessary to fully understand and further think about the current situation of perioperative treatment of esophageal cancer.

Esophageal cancerPerioperative periodImmunotherapyNeoadjuvant chemoradiotherapyPrecise treatment

李祥源、肖蓉、朱美玲

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上海交通大学医学院附属新华医院肿瘤科,上海 200092

食管癌 围手术期 免疫治疗 新辅助放化疗 精准治疗

2024

肿瘤
上海市肿瘤研究所

肿瘤

CSTPCD
影响因子:1.112
ISSN:1000-7431
年,卷(期):2024.44(1)
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