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胰腺癌免疫治疗生物标志物的研究进展

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胰腺癌是常见的消化道恶性肿瘤之一,发病率逐年上升,已成为全球最重要的公共卫生问题之一.当前肿瘤治疗已全面进入免疫治疗时代,但胰腺癌患者对免疫检查点抑制剂的治疗反应并不理想,同时也缺乏有效的、经过验证的生物标记物对可能受益于免疫治疗的患者进行筛选.本文综述当前胰腺癌免疫治疗生物标志物的研究进展,以期帮助临床医师系统地了解相关生物标志物,进而指导胰腺癌的精准治疗.
Research progress of biological markers for immunotherapy in patients with pancreatic cancer
Pancreatic cancer is one of the common gastrointestinal malignancies,the incidence of which is increasing year by year and has become one of the most important public health problems worldwide.At present,tumor treatment has entered the era of immunotherapy,but the response of pancreatic cancer patients to immune checkpoint inhibitors is not ideal.In addition,there is a lack of effective and validated biomarkers to stratify patients who may benefit from immunotherapy.This review has summarized the current research advances of immunotherapeutic biomarkers in pancreatic cancer,hoping to help clinicians understand relevant biomarkers systematically and guide the precise treatment of pancreatic cancer.

Pancreatic cancerImmunotherapyBiomarker

蒋安一、刘宇智、权明

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同济大学附属东方医院肿瘤科,上海 200120

胰腺癌 免疫治疗 生物标志物

国家自然科学基金上海市科技创新行动计划自然科学研究项目上海市浦东新区卫生系统学科带头人培养计划

8197228023ZR1452300PWRd2022-02

2024

肿瘤
上海市肿瘤研究所

肿瘤

CSTPCD
影响因子:1.112
ISSN:1000-7431
年,卷(期):2024.44(1)
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