Associations of early-life exposures with the risk of colorectal cancer:an analysis based on the UK Biobank
Objective:To evaluate the associations of exposures in early-life with the risk of colorectal cancer(CRC)using the UK Biobank(UKB)data.Methods:A total of 462 253 participants from the UKB were included in this analysis.For each subject,self-reported exposures in early-life from the baseline data collected in 2006-2010,which included maternal smoking,single or multiple birth,birth weight,breastfeed as baby,comparative body size and height at age 10,relative age of first facial hair(for males)and age at menarche(for females),were extracted.The incident cases of CRC and all-cause deaths during the follow-up period up to December 31,2021 were further obtained.COX proportional hazards regression models were applied to evaluate the hazard ratio(HR)and 95%confidence interval(CI)of early-life exposures with the risk of CRC after adjusting for age,gender,race family history of CRC,body mass index,family income,and education level at baseline.Results:After adjustment for potential confounding,high birth weight(>4 kg),breastfeed as baby,comparative height at 10(shorter)and relative age at first facial hair(later)were associated with the risk of CRC,with an HR(95%CI)of 1.14(1.03-1.25),1.33(1.24-1.43),0.92(0.85-0.98)and 0.80(0.76-0.95),respectively.Several associations were found to be modified by lifestyle factors in adulthood.Conclusion:Our results indicated that the exposures in early-life,especially during adolescence,may contribute to the development of CRC.These results help to better understand the etiology and mechanisms of CRC,and provide evidence for decision making in CRC prevention.
Colorectal cancerRisk factors in early-lifeCohort study
NETL
NSTL
万方数据
