葡萄膜黑色素瘤肝转移:机制及治疗策略
Liver metastasis of uveal melanoma:mechanism and treatment strategy
张王玲 1赵莲君 2任宇 2邹征云2
作者信息
- 1. 南京大学医学院附属鼓楼医院综合肿瘤中心,江苏 南京 210008
- 2. 南京大学医学院附属鼓楼医院综合肿瘤中心,江苏 南京 210008;南京大学临床肿瘤学研究所,江苏 南京 210008
- 折叠
摘要
葡萄膜黑色素瘤起源于眼球壁中层的葡萄膜,有显著的肝转移倾向,一旦发生转移,预后较差.目前,葡萄膜黑色素瘤的主要治疗方案有包括肝部分切除、消融、肝脏隔离灌注和经皮肝灌注、肝动脉灌注化疗、肝动脉插管化疗栓塞术、免疫栓塞和放射性栓塞术在内的肝脏定向治疗方法以及转移性葡萄膜黑色素瘤的全身治疗方法.本文对葡萄膜黑色素瘤肝转移的发病机制进行讨论,并对葡萄膜黑色素瘤的治疗方法进行综述.
Abstract
Uveal melanoma originates from the uveal tract and has a significant tendency to liver metastasis.Once metastasis occurs,the prognosis is poor.The current treatment options for uveal melanoma are liver-directed therapies including liver partial resection,ablation,isolated hepatic perfusion and percutaneous hepatic perfusion,hepatic artery infusion chemotherapy,transcatheter arterial chemoembolization,immune embolization,and radioembolization,and systemic treatment for metastatic uveal melanoma.This review discusses the pathogenesis of liver metastasis in uveal melanoma and reviews the current treatment options for uveal melanoma.
关键词
葡萄膜黑色素瘤/肝转移/机制/局部治疗/全身治疗Key words
Uveal melanoma/Liver metastasis/Mechanism/Local treatment/Systemic treatment引用本文复制引用
出版年
2024
NETL
NSTL
万方数据