光动力治疗与肿瘤免疫的研究进展
Research advances in photodynamic therapy and anti-tumor immunity
俞阳 1俞荣 2邓小博 2张佳怡 2韩晓雯 2谷保红 2李海元 2陈昊3
作者信息
- 1. 浙江大学医学院附属第二医院甲状腺外科,浙江 杭州 310000
- 2. 兰州大学第二医院肿瘤外科,甘肃 兰州 730030;兰州大学第二临床医学院肿瘤外科,甘肃 兰州 730030;兰州大学第二医院甘肃省消化系肿瘤重点实验室,甘肃 兰州 730030
- 3. 兰州大学第二医院肿瘤外科,甘肃 兰州 730030;兰州大学第二医院甘肃省消化系肿瘤重点实验室,甘肃 兰州 730030
- 折叠
摘要
光动力治疗(photodynamic therapy,PDT)传统上作为一种局部治疗手段,主要用于恶性肿瘤的局部根治和姑息治疗.然而,近年来越来越多的证据显示PDT具有抗肿瘤免疫效应,从而使PDT重新进入了人们的视野.PDT可诱导肿瘤细胞的免疫原性死亡,同时激活固有和适应性免疫系统,增强抗肿瘤免疫反应.本文对PDT与肿瘤免疫的最新进展进行综述,以期系统阐明PDT在抗肿瘤免疫反应中的作用及其在免疫治疗中的应用潜力.
Abstract
As one of traditional local treatments,photodynamic therapy(PDT)has mainly been used for the local eradicate and palliative treatment of malignant tumors.However,in recent years,more and more evidence has revealed a role of PDT in anti-tumor immunity,which attacked attention from researchers again.PDT can induce the immunogenic death of tumor cells as well as activation of both innate and adaptive immune systems,resulting in the enhancement of immune response against tumors.This article reviewed the advances regarding PDT and tumor immunity,aiming to systematically clarify the role of PDT in anti-tumor immunity and its potential applications in immunotherapy.
关键词
肿瘤免疫/光动力/免疫治疗Key words
Anti-tumor immunity/Photodynamic therapy/Immunotherapy引用本文复制引用
出版年
2024
NETL
NSTL
万方数据