炎症研究现状与进展
Current status and advances in inflammation research
谢海伦 1石汉平1
作者信息
- 1. 首都医科大学附属北京世纪坛医院肿瘤营养与代谢中心/临床营养科,国家市场监管重点实验室(肿瘤特医食品),北京肿瘤代谢与营养国际科技合作基地,北京 100038
- 折叠
摘要
炎症是自身免疫系统对外界刺激的防御反应,能够在各种有害条件下维持组织稳态.然而,炎症反应会导致暂时性的组织功能下降,这反过来也是许多疾病发生的机制之一.因此,当炎症反应过度或持续存在时,会促进多种慢性疾病的发展,例如心血管疾病、恶性肿瘤、糖尿病、慢性肾病以及代谢相关脂肪性肝病(MAFLD)等.从生命的早期阶段起,炎症在我们伤口愈合和感染康复中扮演着至关重要的角色,而到了老年时,我们可能会遭受各种慢性炎症性疾病的折磨.人类生命过程与炎症息息相关,炎症不仅是一种保护因素,同时也可能是一种致病因素,贯穿了整个生命周期.因此,全面了解炎症并尝试采取措施来减轻炎症对健康的影响十分重要.本文旨在系统介绍炎症相关进展.通过系统性地探讨炎症理论发展史、炎症发生模式、炎症分类、炎症作用以及炎症调控等内容,以期为炎症相关疾病的干预和治疗提供新的思路和方向.
Abstract
Inflammation is a defensive response of the body's immune system to external stimuli,capable of maintaining tissue homeostasis under various harmful conditions.Inflammation is the body's immune system's defensive response to external stimuli,capable of maintaining tissue homeostasis under various harmful conditions.However,the side effect of the inflammatory response is a temporary decrease in tissue function,which is one of the mechanisms underlying many diseases.Therefore,when inflammation is excessive or persistent,it can promote the development of various chronic diseases,such as cardiovascular disease,malignant tumors,diabetes,chronic kidney disease,and non-alcoholic fatty liver disease.Human life process is closely related to inflammation.Inflammation is not only a protective factor,but also a potentially pathogenic factor that runs throughout the entire life cycle.Therefore,it is important to have a comprehensive understanding of inflammation and to take measures to mitigate its impact on health.The purpose of this review is to systematically review the progress of inflammation.By systematically discussing the history of inflammation theory,the pattern of inflammation,the classification of inflammation,the role of inflammation and the regulation of inflammation,we hope to provide new ideas and directions for the intervention and treatment of inflammation-related diseases.
关键词
炎症/炎症发生模式/炎症分类/炎症调控Key words
Inflammation/Patterns of inflammation onset/Classification of inflammation/Regulation of inflammation引用本文复制引用
基金项目
国家重点研发计划(2022YFC2009600)
国家重点研发计划(2022YFC2009601)
首都医科大学临床医学实验室项目(2023-SYJCLC01)
青年人才托举工程项目(CAST2022QNRC001)
出版年
2024
NETL
NSTL
万方数据