Correlation analysis of nutritional status with liver function,inflammatory factors and prognosis in patients with liver cancer
Objective To investigate the Correlation analysis of nutritional status with liver function,inflammatory factors and prognosis in patients with liver cancer.Method The clinical data of 170 patients with primary hepatocellular carcinoma admitted for hemihepatectomy treatment in Bayannur Hospital from January 2019 to December 2020 were selected for retrospective analysis.The patients were grouped by the subjective overall nutritional status assessment scale(PG-SGA)assessment results,with 0-≤1 group(13 cases),2-≤3 group(34 cases),4-≤8 group(58 cases),and≥9 group(65 cases).We compared the differences in liver function indexes and inflammatory factor levels of patients in each group,analyzed the correlation between PG-SGA scores and liver function indexes and inflammatory factor levels,and compared the prognostic survival status of the well-nourished group(group 4～≤8 + group≥9),and the malnourished group(group 0～≤1 + group 2-≤3).Result Direct bilirubin(DBIL),total bilirubin(TBIL),aspartate aminotransferase(AST),alanine aminotransferase(ALT),interleukin-6(IL-6),tumor necrosis factor-a(TNF-α),and interleukin-1(IL-1)were higher than those in subgroups 0-≤1,2-≤3,and 4-≤8,respectively,in patients of subgroups≥9 of PG-SGA(F= 20.870,18.633,835.004,1190.48,26.283,28.242,31.109,P<0.05),and albumin(ALB)were lower than subgroups 0-≤1,2-≤3,and 4-≤8,respectively(F=-18.755,P<0.05).Person correlation analysis showed that PG-SGA score had a negative correlation with ALB(r=-0.403,P<0.05)and a positive correlation with DBIL,TBIL,ALT,AST,TNF-α,IL-1,IL-6(r=0.412、0.451、0.862、0.849、0.530、0.543、0.515,P<0.05).Kaplan-Meier survival Analysis showed that overall survival was better in the well-nourished group than in the malnourished group(χ2=6.364,P<0.05).Conclusion Most liver cancer patients have malnutrition,and the nutritional status is closely related to liver function,inflammation factor and prognosis.The more severe the malnutrition is,the worse the liver function is,the more severe the inflammation level is,and the worse the prognosis is;clinics need to focus on monitoring the nutritional status of liver cancer patients to ensure that patients have good nutritional status before surgery.
NETL
NSTL
万方数据
