ω-3 polyunsaturated fatty acids(PUFAs)are essential structural and functional nutrients in humans,with numerous studies demonstrating their lipid-lowering,anti-inflammatory,cardiovascular protective,and tumor microenvironment-improving effects.However,the inconsistent results from ω-3 PUFAs intervention trials hinder their widespread application in medical guidelines and limit their clinical use in disease management.As another class of polyunsaturated fatty acids,ω-6 PUFAs are commonly found in excess in global diets,leading to an imbalance in the ω-6/ω-3 ratio and potentially impeding the health effects of ω-3 PUFAs.Research has shown that high ω-6/ω-3 ratios may hinder the beneficial effects of ω-3 PUFAs and are closely associated with the development of numerous chronic diseases due to cellular membrane structure competition and metabolic interference between ω-6 and ω-3 PUFAs.This review analyzes the interaction between ω-3 and ω-6 PUFAs in the body and highlights the importance of the ω-6/ω-3 ratio in modulating the effects of ω-3 PUFAs.Furthermore,it emphasizes that the oversight of the ω-6/ω-3 ratio in previous ω-3 PUFAs studies may be a key reason for inconsistent results,suggesting the need to standardize research protocols and include the ω-6/ω-3 ratio as a quality control parameter to objectively elucidate the health effects of ω-3 PUFAs and promote their standardized application in disease management.
维普
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