首页|免疫治疗在局部晚期鼻咽癌中的研究进展

免疫治疗在局部晚期鼻咽癌中的研究进展

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  • NSTL
  • 万方数据
鼻咽癌起病隐匿,恶性度高,超过 70%的患者在初诊时即为中晚期阶段,目前新辅助化疗联合同步放化疗(CCRT)作为局部晚期鼻咽癌(LA-NPC)的标准治疗手段,虽然具有较好的疾病缓解率,但对一些患者远处转移风险仍然存在.随着免疫治疗的快速发展,基于程序性死亡-1/程序性死亡配体-1(PD-1/PD-L1)阻断的免疫检查点抑制剂(ICIs)在中国取得突破性进展,PD-1 抑制剂联合化疗已作为复发或转移性鼻咽癌(R/M NPC)的一线治疗药物,同时免疫治疗在LA-NPC的治疗中取得新突破,许多前瞻性临床研究正在进行中.在本综述中,根据已发表的临床数据和正在进行的试验,全面概述LA-NPC免疫治疗的基本原理和重要研究成果,以期为临床实践和未来的临床研究提供见解.
Current progress of immunotherapy in locally advanced nasopharyngeal carcinoma
Nasopharyngeal carcinoma(NPC)has an insidious onset,and it exhibits a high degree of malignancy.More than 70%of the patients are in middle or advanced stage at the time of initial diagnosis.Currently,neoadjuvant chemotherapy combined with concurrent chemoradiotherapy(CCRT)is used as the standard treatment for locally advanced NPC(LA-NPC).Although it has a good remission rate,the risk of distant metastasis still exists in some patients.With the rapid development of immunotherapy,immune checkpoint inhibitors(ICIs),especially programmed death-1/programmed death ligand-1(PD-1/PD-L1)blockade,have made breakthroughs in China.PD-1 inhibitors combined with chemotherapy have been used as the first-line treatment for recurrence and/or metastatic NPC(R/M NPC).Meanwhile immunotherapy has made new breakthroughs in the treatment of LA-NPC,and many prospective clinical studies are underway.In this review,we provide a comprehensive overview of the fundamentals of immunotherapy for LA-NPC patients and important research findings in immunotherapy in LA-NPC based on published clinical data and ongoing trials,with the aim of providing insights for clinical practice and future clinical studies.

ImmunotherapyLocally advanced nasopharyngeal carcinomaNeoadjuvant chemotherapyImmune checkpoint inhibitorsProgrammed death-1Programmed death ligand-1RecurrenceBiomarkers

黄宁欣、何佳琦、罗海清

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广东医科大学附属医院头颈部肿瘤专科,广东 湛江 524000

免疫治疗 局部晚期鼻咽癌 新辅助化疗 免疫检查点抑制剂 程序性死亡-1 程序性死亡配体-1 复发 生物标志物

广东省教学改革项目广东省湛江市科技发展专项资金竞争性分配项目广东省湛江市科技发展专项资金竞争性分配项目广东医科大学附属医院临床研究项目广东医科大学附属医院临床研究项目

2FY230502023A2062021A05084LCYJ2019A001LCYJ2021A002

2024

10.16689/j.cnki.cn11-9349/r.2024.04.004

肿瘤代谢与营养电子杂志

肿瘤代谢与营养电子杂志

CSTPCD
ISSN：
年,卷(期)：2024.11(4)