An observational study of sarcopenia and body fat level in cirrhotic patients
Objective To analyze muscle and body fat levels in cirrhotic patients,as well as investigate the association between liver disease severity and muscle and body fat in patients with cirrhosis.Method All study participants were cirrhosis patients who were hospitalized at Southwest Medical University's Affiliated Hospital from November 2022 to November 2023.A cross-sectional study was used to collect data on cirrhotic patients' general condition,blood routine,biochemical tests,anthropometric measurements,etc.Measurement of skeletal muscle index (L3-SMI),visceral fat area (VFA),and subcutaneous fat area (SFA) of abdominal CT at the level of the 3rd lumbar vertebrae using Sliceomatic 5.0 image analysis software.The Geriatric Nutritional Risk Index (GNRI) was analyzed.VFA and SFA were correlated with L3-SMI,triceps skinfold thickness (TSF),and mid-arm circumference (MAC),respectively.To compare the levels of body fat and muscle measured by CT in subgroups with different Child-Pugh classifications and MELD scores.Result A total of 203 patients with liver cirrhosis were included,86 patients with sarcopenia (42.4％),and 117 patients with non-sarcopenia (57.6％).Body mass index (BMI),hand grip strength (HS),MAC,TSF,calf circumference (CC),VFA,SFA,visceral adiposity index (VATI),and subcutaneous adiposity index (SATI) were lower in patients with cirrhosis combined with sarcopenia than in patients with non-sarcopenia (P<0.05).VFA correlating most strongly with MAC (r=0.595,P<0.001) and SFA correlating most strongly with TSF (r=0.753,P<0.001).Child-Pugh score grade C had lower VFA,SFA,VATI,and SATI than Child-Pugh score grade A versus B (P<0.05),L3-SMI was not statistically different between groups,and all of the above indicators were lower in the MELD score>11 subgroup than in the MELD score ≤11 subgroup (P<0.05),and L3-SMI was again not statistically different between groups.Conclusion When sarcopenia occurred in patients with cirrhosis,body fat levels also decreased and decreased with increasing disease severity,but no significant changes in muscle levels were observed.
万方数据
维普
