R516A is one of the new substitutes for R134a refrigerant in water-cooled chillers.The COP(coefficient of performance)and discharge temperatures of R516A and R134a are compared through a single-stage vapor compression cycle.Under nominal and variable operating conditions,the performances of a small water-cooled chiller charged with R134a and R516A are tested and compared.The cost changes of replacing R134a with R516A in the water-cooled chiller are discussed.The conclusions indicate that,in the theoretical cycle,the COP of R516A is 1.5%lower than that of R134a,and the discharge temperature is 4.9-6.0℃lower than that of R134a.Under nominal operating conditions,there is a certain performance gap between the R516A chiller and the R134a chiller,with a COP difference of 4.9%-7.2%.Under variable operating conditions,the performance of the R516A chiller is basically equivalent to that of the R134a chiller,and the COP gap is reduced to 0.5%-2.3%.Owing to the mild flammability of R516A,the cost of the R516A chiller is 10%-15%higher than that of the R134a chiller.