首页|Role of liquid-liquid phase separation in cancer:Mechanisms and therapeutic implications
Role of liquid-liquid phase separation in cancer:Mechanisms and therapeutic implications
扫码查看
点击上方二维码区域，可以放大扫码查看
原文链接
NETL
NSTL
万方数据
Liquid-liquid phase separation(LLPS)has emerged as a pivotal biological phenomenon involved in various cellular processes,including the formation of membrane-less organelles and the regulation of biomolecular condensates through precise spatiotemporal coordination of signaling pathways in cells.Dysregulation of LLPSs results in aberrant biomolecular condensates,which are widely implicated in tumorigenesis and cancer progression.Here,we comprehensively summarize the multifaceted roles of LLPS in tumor biology from the perspective of cancer hallmarks,including genomic stability,meta-bolic reprogramming progression,ferroptosis,and metastasis,to unveil the intricate mechanisms by which LLPS occurs in tumorigenesis.We discuss current discoveries related to therapeutic involvement and potential clinical applications of LLPS in cancer treatment,highlighting the potential of tar-geting LLPS-driven processes as novel therapeutic strategies.Additionally,we discuss the challenges associated with new approaches for cancer treatment based on LLPS.This in-depth discussion of the impact of LLPS on funda-mental aspects of tumor biology provides new insights into overcoming cancer.
cancerliquid-liquid phase separationmechanism
Xuesong Li、Zhuo Yu
展开 >
School of Clinical Medicine,Tsinghua University,Beijing,China
Department of Medical Oncology,Beijing Tsinghua Changgung Hospital,Beijing,China
NETL
NSTL
万方数据
