预后评分系统GPA在肺癌脑转移患者中的应用
Application of Prognostic Index Graded Prognostic Assessment (GPA) in Lung Cancer with Brain Metastases
童海光 1谢聪颖 2林权冰3
作者信息
- 1. 温州市洞头县人民医院,浙江洞头325700
- 2. 温州医科大学附属第一医院,浙江温州325000
- 3. 温州市中心医院,浙江温州325000
- 折叠
摘要
[目的]评价GPA(raded prognostic assessment)分级在评价肺癌脑转移瘤患者预后中的作用.[方法]回顾性分析109例肺癌脑转移患者的临床资料,按GPA系统进行GPA评分,采用Kaplan-Meier进行生存分析并进行Log-rank检验.[结果]单因素分析显示患者的Karnofsky评分(KPS评分)、脑转移灶数目、颅外转移对肺癌脑转移患者生存期有影响(P＜0.05).GPA 0～1分组中位生存期为8个月(95％CI:4.64～11.36),1.5～2.5分组中位生存期12个月(95％CI:9.16～14.83),3～4分组中位生存期25个月(95％CI:5.87～44.13).不同GPA评分患者的中位生存期差异有统计学意义(x2=-7.467,P=0.024).[结论]GPA作为一个预后模型,是有用的肺癌脑转移预测模型.
Abstract
[Purpose] To investigate the role of graded prognostic assessment(GPA) in the evaluation of prognosis for lung cancer patients with brain metastasis.[Methods] The clinical data of 109 lung cancer patients with brain metastases were reviewed retrospectively.GPA were evaluated according to GPA system.Survival was analyzed with Kaplan-Meier method and Log-rank test was used.[Results] The univariate analysis showed that Karnofsky score (KPS score),number of brain metastases,extracranial metastasis had influence on survival of lung cancer patients with brain metastases (P＜0.05).The median survival was 8 months(95％CI:4.64～11.36) in group with GPA 0～1,12 months (95％CI:9.16～14.83) in group with GPA 1.5～2.5,25 months (95％CI:5.87～44.13) in group with GPA 3～4.The median survival of patients with different GPA score were statistically significant (x2=7.467,P=0.024).[Conclusion] GPA is useful for prediction of brain metastases from lung cancer.
关键词
肺肿瘤/脑转移/预后/分级预后评估(GPA)Key words
lung cancer/brain metastasis/prognosis/graded prognostic assessment(GPA)引用本文复制引用
出版年
2014
NETL
NSTL
维普
万方数据