Association of HER2 Expression Levels with Clinicopathological Features and Prognosis in Patients with Early Breast Cancer
[Objective]To compare the clinicopathological features and prognosis in early breast cancer pa-tients with different human epidermal growth factor receptor 2(HER2)protein expression levels.[Methods]The clinicopathological data of 792 patients with stage Ⅰ～Ⅱ breast cancer admitted to the Department of Thyroid and Breast Surgery of Affiliated Hospital of Inner Mongolia Medical University from June 2010 to June 2019 were retrospectively analyzed,including 301 cases of HER2 zero expression,309 cases of HER2 low expression and 182 cases of HER2 positive.The clinicopathological features and prognosis among three groups were compared.[Results]There were significant differences in proportions of histological and molecular subtypes and clinicopathological features among three groups.Patients with HER2 low expression had higher proportion of Luminal A subtype,and lower proportion of triple-negative breast cancer(TNBC).Compared with patients with HER2 zero expression,patients with HER2 low expression had a higher pro-portion of positive axillary lymph nodes,lympho-vascular invasion and hormone receptor(HR)positive,and a lower proportion of invasive lobular carcinoma,high histological grade and high Ki-67 expression.A total of 792 patients were followed up with median follow-up time 56 months.The 5-year disease free survival(DFS)of patients with positive expression of HER2,low expression of HER2,and zero expression of HER2 were 85.7％,92.9％,and 91.3％,respectively(x2=8.268,P=0.016),5-year overall survival(OS)were 92.8％,97.4％,96.8％(x2=15.809,P＜0.001),respectively.There was no significant difference in 5 years DFS at after stratified analysis by HR status.[Conclusion]HER2 low expression breast cancer has unique clinico-pathological features,but there is no significant difference in prognosis between of patients with HER2 low expression and HER2 zero expression,so this study does not support low HER2 breast cancer as an inde-pendent biological subtype.
breast cancerHER2 low expressionclinicopathological featureprognosis
万方数据
维普
