Clinicopathologic Features and Prognosis of 226 Cases of Breast Cancer Complicated with Type 2 Diabetes Mellitus
[Objective]To analyze the clinicopathological features and prognosis of invasive breast cancer patients complicated with type 2 diabetes mellitus(T2DM).[Methods]Among breast cancer patients treat-ed in Department of Breast Surgery,the First Affiliated Hospital of Zhejiang University School of Medicine from 2015 to 2018,226 cases were breast cancer complicated with T2DM,and 788 cases without diabetes were randomly selected as non-T2DM group.The clinicopathological features and prognosis of the two groups were compared.Then two groups were matched by 1∶1 propensity matching,the dis-ease-free survival(DFS)and breast cancer-specific survival(BCSS)were analyzed by Kaplan-Meier method,and factors influencing the recurrence of breast cancer and prognosis of patients were examined by Cox regression analysis.[Results]The average age was older,the tumor size was larger,the histological grade was higher,the DFS and BCSS were shorter in T2DM patients than those in non-T2DM patients(all P＜0.05).Multivariate Cox regression analysis indicated that T2DM was an independent factor for prognosis of breast cancer patients(HR=1.760,95％CI:1.101～2.672).and also an independent factor for breast cancer-specific death(HR=1.724,95％CI:1.018～3.122).[Conclusion]The prognosis of breast cancer patients complicated with T2DM is relatively poor,and special attention should be given to this group of patients.
type 2 diabetes mellitusbreast cancerdisease-free survivalbreast cancer specific survival
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维普
