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代谢组学在恶性肿瘤研究中的应用进展

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代谢组学是一种系统性研究生物体内代谢物质组成和变化规律的高通量技术,以探究代谢物在生物体内的作用和调控机制.代谢重编程是恶性肿瘤的重要特征之一.在肿瘤的发生和进展过程中,生物体内代谢谱会发生变化.近年来,代谢组学技术已在恶性肿瘤研究中得到广泛应用,包括肿瘤筛查、早期诊断、疗效预测、预后评估和新药靶点研发等.全文总结代谢组学在恶性肿瘤研究进展,揭示代谢组学技术在临床应用中的潜在价值.
Advances on Application of Metabolomics in Cancer Research
Metabolomics is a systematic study of the composition and changes of metabolites in the organism using high-throughput technique to explore their roles and regulatory mechanism.Metabolic reprogramming is one of the major hallmarks of malignant tumors.During the tumori-gensis and progression,metabolic profiles in the organism undergo significant alterations,there-fore metabolomics is an important tool in cancer research.In recent years,metabolomics tech-niques have been widely applied in cancer research,including cancer screening,early diagnosis,efficacy prediction,prognosis evaluation,and new drug targets identification.This paper reviews the recent advances of metabolomics in cancer research focusing on the potential value of metabolomics techniques in clinical application.

malignant tumormetabolitemetabolomicsbiomarker

文英美、姚颐

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武汉大学人民医院肿瘤中心,湖北武汉 430060

恶性肿瘤 代谢物 代谢组学 生物标志物

湖北省自然科学基金一般项目

2022CFB114

2024

肿瘤学杂志
浙江省肿瘤医院 浙江省抗癌协会

肿瘤学杂志

CSTPCD
影响因子:0.83
ISSN:1671-170X
年,卷(期):2024.30(1)
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