Progress on Abnormal Immune Microenvironment and Thymic Epithelial Tumors
The thymus is an important organ for T lymphocyte development and the formation of T-cell receptors,playing a critical role in adaptive immunity and central tolerance establishment.Progenitor T cells migrate from the bone marrow to the thymus during early developmental stages and interact with thymic epithelial cells in the cortical and medullary regions of thymus.Through positive and negative selection processes,these progenitor T cells differentiate into mature T lymphocytes,contributing to the unique microenvironment of the thymus.Thymic epithelial tumors are common primary tumors in the anterior mediastinum,characterized by the abnormal proliferation of epithelial cells often accompanied by a large number of immature lymphocytes,which can potentially lead to autoimmune clinical symp-toms.However,the exact molecular regulatory mechanisms and the underlying pathogenesis of these tu-mors remain unclear.This paper reviews the research progress on the disruption of immune microenvi-ronment in tymus during the occurrence and development of thymic epithelial tumors.
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