Distribution Characteristics of Visually Accessible Rembrandt Images Features in Patients with Lower-Grade Glioma
[Objective]To analyze and compare the level and distribution characteristics of the Visually Accessible Rembrandt Images(VASARI)feature score in patients glioma(WHO grade 2-3)and to ex-plore potential predictors of glioma grading,aiding clinical identification and management.[Methods]Molecular markers and imaging data of 95 patients pathologically diagnosed as WHO grade 2-3 glioma(64 WHO grade 2 and 31 WHO grade 3)in Huashan Hospital of Fudan University from 2011 to 2018 were retrospectively collected.The differences in the total VASARI score and the distribution of imag-ing features between patients with different grades of glioma were compared separately using SAS 9.4 software.[Results]The mean age of the 95 subjects was 44.00±11.24 years old,of which 50(52.63％)were male.The total VASARI score was significantly higher(Z=4.23,P＜0.001)in patients with WHO grade 3 glioma(median:66.00)than those in patients with WHO grade 2 glioma(median:55.00).The distribution of isocitrate dehydrogenase(IDH)status,O6-methylguanine DNA methyltransferase(MGMT)status,enhancement quality,proportion of enhancing tumor,proportion of non-enhancing tumor,pro-portion of necrosis,cyst,T1/FLAIR ratio,the thickness of enhancing margin,the definition of en-hancing margin,the definition of non-enhancing margin,proportion of edema,edema crosses the midline,deep white matter invasion,enhancing tumor crosses the midline,and lesion size were statis-tically significant between patients with grade 2 and grade 3 glioma(P＜0.05).[Conclusion]The total VASARI scores and the distribution of imaging features were statistically significant between grade 2 and grade 3 glioma patients,with imaging features related to enhancement,non-enhancement,cyst,necrosis,edema,and lesion size being relevant factors in grading glioma patients.
gliomaVisually Accessible Rembrandt Imagesisocitrate dehydrogenasemagnetic resonance imaging
NETL
NSTL
万方数据
