Progress on Immunotherapy Combined with Chemotherapy,Radiotherapy and Targeted Therapy for Brain Metastasis of Small Cell Lung Cancer
Brain metastasis of small cell lung cancer is a challenge for conventional therapies.However,the combination of immunotherapy with chemotherapy,radiotherapy and targeted thera-py provides a new option for small cell lung cancer patients with brain metastases.Chemotherapy combined with immunotherapy has been a first-line treatment for extensive small cell lung cancer,and its efficacy for brain metastasis patients has been also confirmed.Brain radiation therapy combined with immunotherapy is a new approach,although not explicitly mentioned in clinical guidelines.Based on the molecular mechanism and results of small-sample studies,the combina-tion approach tends to be recommended as a synchronous therapy.The efficacy of anti-angiogenic drugs combined with immunotherapy is better than that of single drug,and the adverse reactions are also within the acceptable range.This paper reviews the recent progress on immunotherapy in the treatment of brain metastases of small cell lung cancer,and further discusses the efficacy and related side effects of immunotherapy combined with chemotherapy,radiotherapy and targeted therapy.
small cell lung cancercentral nervous system metastasisimmunotherapycombination therapyadverse reactions
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