Advances on Discoidin Domain Receptors and Tumor Immunity
The abnormal expression of discoidin domain receptors(DDRs)has been revealed in tu-mor tissues,which is involved in tumor cell adhesion,migration,proliferation and stromal re-modeling,and plays an important role in tumor immune response.Recently,some small-molecule inhibitors of DDRs have shown preliminary clinical efficacy in a variety of solid tumors.This pa-per reviews the research advances on the DDRs and tumor immunity,focusing on the interactions between DDRs and the tumor immune microenvironment,and the application of DDRs as a new target for anti-tumor therapy,and also discusses the prospects and challenges of the DDRs-target-ed immunotherapy for a wide range of solid tumors.
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