Radiation Therapy for Tumors in the Pineal Region:A Single-Center Experience of 29 Cases
[Objective]To observe the therapeutic efficacy and prognosis of radiotherapy for pineal re-gion tumor and to explore the differences in therapeutic efficacy between different radiotherapy regi-mens.[Methods]Clinical data of 29 patients with pineal region tumor receiving initial radiotherapy at Jiangsu Cancer Hospital from April 2008 to September 2022 were retrospectively analyzed,including 10 cases of primary site radiotherapy(PSRT),4 cases of whole brain+primary boost radiotherapy(WBRT+PB),3 cases of whole ventricle+primary boost radiotherapy(WVI+PB),and 12 cases of cran-iospinal irradiation+primary boost radiotherapy(CSI+PB).The overall survival and progression-free sur-vival were analyzed by Kaplan-Meier method and survival curve was drawn.[Results]The overall sur-vival of 29 patients at 3-year,5-year and 10-year were 92.5％,92.5％and 74.0％,respectively.The 3-year,5-year and 10-year progression-free survival rates were 88.6％,88.6％and 79.8％,respective-ly.Among the 29 patients,4 experienced recurrence,including 1 case in PSRT group,1 cases in WBRT+PB group and 2 case in WVI+PB radiotherapy group.Among the 4 recurrence patients,3 cases died,including 2 case in the WVI+PB group and 1 cases in WBRT+PB group.Additionally,1 case experienced intracranial recurrence after primary site radiotherapy but was successfully salvaged through whole brain and whole spinal cord irradiation.[Conclusion]Radiotherapy is a fundamental component of the multidisciplinary treatment approaches for most pineal region tumors.For patients with a poorer prognosis,whole brain and whole spinal cord irradiation may have superior disease con-trol,comparatively.
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