脑胶质瘤与铁死亡研究进展
Research Progress on Relationship Between Brain Glioma and Ferroptosis
洪喆 1毛欣晨 1侯翔云 1王安琪 1冯海忠 1孙博文1
作者信息
- 1. 上海交通大学医学院附属仁济医院临床干细胞研究中心,上海 200127
- 折叠
摘要
基于脑胶质瘤发病过程中的信号通路寻找治疗靶点成为探索脑胶质瘤新型治疗方式的重点领域.铁死亡是一种由脂质过氧化驱动的铁依赖性的细胞死亡方式,已被证实其参与多种肿瘤(包括脑胶质瘤)的发生及进展进程.全文回顾铁死亡的经典代谢途径,总结已有研究中常用的铁死亡诱导剂、抑制剂以及脂质过氧化的评估方法,梳理铁死亡与脑胶质瘤相关研究中的最新发现,包括铁死亡关键调节因子在脑胶质瘤中的表达情况、脑胶质瘤生理环境对铁死亡的影响及脑胶质瘤治疗药物与铁死亡的关系等,为脑胶质瘤的靶向治疗药物研发提供参考.
Abstract
Currently,finding therapeutic targets based on signaling pathways in the pathogenesis of gliomas has become a research hot point for exploring novel therapeutic modalities of gliomas.Ferroptosis is an iron-dependent cell death driven by lipid peroxidation,found to be involved in the developmental of a variety of malignant tumors,including gliomas.This paper reviews the re-search progress on the classical metabolic pathways of ferroptosis and the relationship between fer-roptosis and gliomas,focusing on the expression of the key regulators in brain gliomas,the influ-ence of the physiological environment of brain gliomas on ferroptosis,and the commonly used fer-roptosis inducers and inhibitors,the lipid peroxidation assessment methods,and related therapeu-tic drugs for brain gliomas.
关键词
脑胶质瘤/铁死亡/脂质过氧化Key words
ferroptosis/glioma/lipid peroxidation引用本文复制引用
基金项目
国家自然科学基金(82103657)
国家自然科学基金(82072896)
上海市优秀学术带头人计划(21XD1403100)
上海交通大学医学院大学生创新性训练计划(1824033)
出版年
2024
NETL
NSTL
万方数据