Research Progress on Relationship Between Brain Glioma and Ferroptosis
Currently,finding therapeutic targets based on signaling pathways in the pathogenesis of gliomas has become a research hot point for exploring novel therapeutic modalities of gliomas.Ferroptosis is an iron-dependent cell death driven by lipid peroxidation,found to be involved in the developmental of a variety of malignant tumors,including gliomas.This paper reviews the re-search progress on the classical metabolic pathways of ferroptosis and the relationship between fer-roptosis and gliomas,focusing on the expression of the key regulators in brain gliomas,the influ-ence of the physiological environment of brain gliomas on ferroptosis,and the commonly used fer-roptosis inducers and inhibitors,the lipid peroxidation assessment methods,and related therapeu-tic drugs for brain gliomas.
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