液-液相分离在癌症中的研究进展
Research Progress on Liquid-Liquid Phase Separation in Cancer
任晨璐 1徐盈 1马博乙 1殷亚东 1陈志浩 1林晓红 1杨红1
作者信息
- 1. 空军军医大学第一附属医院,陕西西安 710032
- 折叠
摘要
细胞内液-液相分离(liquid-liquid phase separation,LLPS)是真核细胞中无膜细胞器形成的一种重要且普遍存在的现象,其自发地将均质溶液分离成两个或多个共存的相(稀相和浓相),这使特定的分子集中在特定的位置,从而形成异质环境.LLPS被证明与多种肿瘤(如白血病、乳腺癌、肉瘤等)的发生及进展密切相关,参与肿瘤增殖、侵袭、转移等生物学过程.全文综述LLPS的发生机制,了解多价分子如何驱动相变形成生物分子凝聚物,并重点介绍了探索相分离和癌症相关过程之间的机制联系,以期为肿瘤治疗提供新的选择.
Abstract
Intracellular liquid-liquid phase separation(LLPS)is a common phenomenon in the for-mation of membraneless organelles in eukaryotic cells.It spontaneously separates a homogeneous solution into two or more coexisting phases(dilute and concentrated),causing specific molecules to be concentrated at specific locations,thus forming a heterogeneous environment.It has been shown that LLPS is closely related to the occurrence and development of a variety of malignant tu-mors(leukemia,breast cancer,sarcoma,etc.).It is involved in various biological activities of ma-lignant tumors,including cell proliferation,invasion and metastasis.Here,we review the mecha-nisms of LLPS formation,focusing on the phase transition to form biomolecular condensates driv-en by multivalent molecules and the link between phase separation and cancer-related processes to provide new insight for cancer treatment.
关键词
液-液相分离/生物分子凝聚物/癌症/肿瘤相关信号通路Key words
liquid-liquid phase separation/biomolecular condensates/cancer/tumor-related signaling pathways引用本文复制引用
基金项目
国家自然科学基金面上项目(82172993)
陕西省自然科学基础研究计划(2022JQ-977)
陕西省创新平台项目(2023PT-07)
出版年
2024
NETL
NSTL
万方数据