Research Advances of Estrogen Receptor α in Gastric Cancer
Gastric cancer is one of the most common malignancies in the world.New treatment modalities such as targeted therapy and immunotherapy may improve the overall survival of gastric cancer patients,but the overall efficacy remains limited.Further exploration of new therapeutic strategies is still needed.Estrogen is a steroid hormone that is involved in regulating various phys-iological and pathological processes by binding to the estrogen receptor(ER).Studies have shown that estrogen receptor-alpha(ERα)is involved in regulating the biological behaviors of gastric cancer cells,such as proliferation,invasion and metastasis.This review summarizes recent re-search advances of ERα in gastric cancer and its role in the development,treatment and progno-sis of gastric cancer,also discusses ERα as a potential therapeutic target for gastric cancer.
gastric neoplasmsestrogen receptor alphaestrogenclinicopathologic features
NETL
NSTL
万方数据
