Expression of CXCR4 mRNA in Gastric Cancer and Its Clinical Significance
[Objective]To investigate the expression of C-X-C Motif chemokine receptor 4(CXCR4)in gastric cancer and its clinical significance.[Methods]The data of CXCR4 mRNA expression in cancer tissues and pericancerous tissues,and pathological parameters of gastric cancer patients were obtained from TCGA database.The expression of CXCR4 mRNA in cancer tissue specimens of 92 gastric cancer patients who underwent gastrectomy in Shaanxi Provincial People's Hospital between July 2018 and November 2022 was detectedby RT-PCR and immunohistochemistry.The correlation of CXCR4 mRNA expression with pathological parameters and prognosis of patients was analyzed.[Results]Both TCGA data and clinical data showed that CXCR4 mRNA expression levels in gastric cancer tissues were significantly higher than those in pericancerous tissues(P＜0.001).TCGA data analysis showed that CXCR4 mRNA expression was positively correlated with tumor infiltration depth(T)and degree of tumor differentiation(OR=1.297 and 1.437,P＜0.05).Clinical data analysis showed that CXCR4 mRNA expression was posi-tively correlated with distant tumor metastasis and the degree of tumor differentiation(OR=7.717 and 3.254,P＜0.05).Both TCGA data and clinical data showed that the survival time of gastric cancer patients with high-expression of CXCR4 mRNA was significantly shorter those with low-expression of CXCR4 mRNA(P=0.008 and 0.001).[Conclusion]CXCR4 mRNA overexpression in gastric cancer tissues is closely related to tumor development,infiltration,and metastasis,and indicates a poor prognosis of patients.CXCR4 mRNA might be a new candidate marker for diagnosis and potential target for treatment in gastric cancer.
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