胃肠胰高级别神经内分泌肿瘤病理诊断现状及研究进展
Current Status and Progress on Pathological Diagnosis of High Grade Gastroenteropancreatic Neuroendocrine Neoplasm
吴晓晓 1许晶晶 1朱利明 1吴伟1
作者信息
- 1. 浙江省肿瘤医院,中国科学院杭州医学研究所,浙江杭州 310022
- 折叠
摘要
根据目前WHO消化系统肿瘤分类中的分级标准,胃肠胰神经内分泌肿瘤可分为低、高级别肿瘤,其中高级别肿瘤包括了分化良好的神经内分泌瘤G3和低分化神经内分泌癌.两者临床病理特征和治疗决策显著不同,是病理诊断工作中的难点.如何较为精准地区分至关重要.全文归纳总结了目前研究中所涉及的这两类肿瘤病理诊断标准以及相关免疫组化、分子标志物研究进展,旨在为临床正确认识该类疾病并制定适宜的精准治疗方案提供更可靠的依据.
Abstract
Gastroenteropancreatic neuroendocrine neoplasm(GEP-NEN)are classified into low-grade and high-grade tumors according to the WHO classification criteria for digestive system tu-mors.The high-grade NEN include well differentiated neuroendocrine tumor G3 and poorly differ-entiated neuroendocrine cancer.The clinical pathological characteristics and treatment options of the two are significantly different,however,it is difficult in differential diagnosis pathologically.This paper summarizes the current pathological diagnostic criteria and research progress on im-munohistochemical and molecular marker of these two types of tumors,to provide reference for the development of appropriate treatment plans.
关键词
胃肠胰肿瘤/神经内分泌瘤/神经内分泌癌/病理诊断Key words
gastroenteropancreatic neoplasm/neuroendocrine tumor/neuroendocrine carcinoma/pathological diagnosis引用本文复制引用
基金项目
浙江省医药卫生科技临床研究应用项目(2022KY103)
出版年
2024
NETL
NSTL
万方数据