Current Status and Progress on Pathological Diagnosis of High Grade Gastroenteropancreatic Neuroendocrine Neoplasm
Gastroenteropancreatic neuroendocrine neoplasm(GEP-NEN)are classified into low-grade and high-grade tumors according to the WHO classification criteria for digestive system tu-mors.The high-grade NEN include well differentiated neuroendocrine tumor G3 and poorly differ-entiated neuroendocrine cancer.The clinical pathological characteristics and treatment options of the two are significantly different,however,it is difficult in differential diagnosis pathologically.This paper summarizes the current pathological diagnostic criteria and research progress on im-munohistochemical and molecular marker of these two types of tumors,to provide reference for the development of appropriate treatment plans.
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