A Systematic Review and Meta-Analysis of Survival Prediction Model for Chinese Patients with Stage Ⅲ～Ⅳ Non-Small Cell Lung Cancer
[Objective]To evaluate the published survival prediction models for Chinese patients with stage Ⅲ～Ⅳnon-small cell lung cancer through systematic review and meta-analysis.[Methods]The relevant studies were retrieved from PubMed,CNKI,Wanfang Data and VIP Data from January 1,2020 to February 29,2024.Data analysis and chart drawing were carried out using STATA/MP18 software,and the risk of bias and applicability of the included literature were evaluated.Meta-analysis was performed on the predictors of the survival prognosis model.[Results]A total of 10 models from 9 studies were finally included in the analysis.The included models had high risk bias,and the prediction performance of the models was good(AUC:0.614～0.915).Metastasis(HR=1.23,95％CI:1.18～1.29),smoking history(HR=1.42,95％CI:1.22～1.64),TNM stage(HR=1.86,95％CI:1.68～2.07),neutrophil/lymphocyte ratio(HR=1.92,95％CI:1.66～2.21),platelet/lymphocyte ratio(HR=3.22,95％CI:1.57～6.61),chemotherapy cycle(HR=0.68,95％CI:0.53～0.87)were the influencing factors of survival for Chinese patients with stage Ⅲ～Ⅳ non-small cell lung cancer.[Conclusion]The published survival and prognosis models for Chinese patients with stage Ⅲ～Ⅳ non-small cell lung cancer are generally effective,but have a high risk of bias and lack external validation.The study indicates that clinicians should pay more atten-tion to patients with smoking history,insufficient chemotherapy,and late stage with metastasis,and conduct in-flammatory factor detection and evaluation at the same time.
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