Research Progress on Multi-Omics Research in Osteosarcoma
Osteosarcoma(OS)is the most common primary malignant bone tumor with highly inva-sive and metastatic properties.With the development of high-throughput sequencing technology,comprehensive omics analysis has been applied clinically,providing new ways for the treatment of various tumors.Abundant data of transcriptome,genome,epigenetic and proteomics provide valu-able information related to gene expression,gene mutations and chemical modifications of OS,deepening our understanding its molecular mechanisms and biological characteristics.In addition,emerging single-cell sequencing can quantify gene expression at the cell level,reveal the molecu-lar characteristics of different cell types,compare cell differences,and even explore the origin of OS.This paper reviews the the current progress of multi-omics research in OS to provide infor-mation and inspiration for the clinical treatment of OS.
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