[目的]探讨cN+对于病理Ⅱ期结直肠癌患者检出淋巴结数目及预后的影响.[方法]收集2004-2015年美国SEER数据库23 565例及2011-2015年中国医学科学院肿瘤医院(Cancer Hospital Chinese Academy of Medical Sciences,CHCAMS)数据中 454 例病理 Ⅱ 期结直肠癌患者的临床基线资料.比较检出淋巴结数目＜12枚和≥12枚两组患者基线资料差异.行Logistic回归分析明确cN+是否是影响检出淋巴结数目的因素.并分析cN+对于检出淋巴结数目≥12枚组患者5年总生存期(overall survival,OS)的影响.[结果]两个数据集中检出淋巴结数目≥12枚组较＜12枚组cN+比例均更高(SEER:4％vs 2％,CHCAMS:52％vs 22％),且cN+均是检出淋巴结数目≥ 12枚的独立影响因素(SEER:OR=1.497,95％CI:1.133～1.979,P=0.005;CHCAMS:OR=2.698,95％CI:1.221～5.960,P=0.014).两个数据集中,检出淋巴结数目≥12枚组患者中cN+组较cN0组均具有更好的5年OS(SEER:80.6％vs 74.9％,HR=0.74,95％CI:0.58～0.95,P=0.01 6;CHCAMS:90.3％vs 83.2％,HR=0.53,95％CI:0.31～0.91,P=0.020).[结论]cN+是检出淋巴结数目≥12枚的影响因素,且对于检出淋巴结数目≥12枚组病理Ⅱ期结直肠癌患者,cN+组具有更好的5年OS.
Significance of cN+for the Number of Harvested Lymph Node and Prognosis of Pathological Stage Ⅱ Colorectal Cancer:A Retrospective Cohort Study from SEER Databases and Chinese Hospital Datasets
[Objective]To explore the significance of cN+for the number of harvested lymph nodes(LN)and prognosis of pathological stage Ⅱ colorectal cancer(CRC).[Methods]The clini-cal information of 23 565 pathological stage Ⅱ CRC patients from 2004 to 2015 in SEER databases and that of 454 pathological stage ⅡCRC patients from 2011 to 2015 in Cancer Hospi-tal Chinese Academy of Medical Sciences(CHCAMS)were analyzed.The baseline characteristics between LN＜12 and LN ≥12 group were compared.And the Logistic regression analysis was con-ducted to investigate whether cN+was the influencing factor of the number of LN or not.The ef-fect of cN+on the 5-year overall survival(OS)of patients within LN ≥12 group was analyzed.[Results]There were higher ratio of cN+in LN≥ 12 group than in LN＜12 group in both datasets(SEER:4％vs 2％,CHCAMS:52％vs 22％).Positive clinical LN stage(cN+)was the signifi-cant independent factor for LN ≥ 12(SEER:OR=1.497,95％CI:1.133～1.979,P=0.005;CHCAMS:OR=2.698,95％CI:1.221～5.960,P=0.014).The cN+group had a better 5-year OS than cNo group in LN≥12 group(SEER:80.6％vs 74.9％,HR=0.74,95％CI:0.58～0.95,P=0.016;CHCAMS:90.3％vs 83.2％,HR=0.53,95％CI:0.31～0.91,P=0.020).[Conclusion]cN+is the influencing factor for LN ≥12;and for pathological stage Ⅱ CRC patients with LN ≥12,cN+is associated with a better 5-year OS.
NETL
NSTL
万方数据
