Relationship of PTEN,P53 and Mismatch Repair Protein Expression with Pathological Features and Prognosis in Patients with Endometrial Cancer
[Objective]To investigate the relationship of the PTEN,P53 and DNA mismatch repair(MMR)proteins expression with the pathological characteristics and prognosis in patients with endometrial cancer.[Methods]The clinical data of 118 patients with endometrial cancer who underwent comprehensive staged surgical treatment at Yuyao People's Hospital from January 2018 to June 2022 were retrospective analyzed.According to the immuno-histochemical results,patients were divided into PTEN mutation group,P53 mutation group,and deficient mis-match repair(dMMR)group,and the pathological characteristics and prognosis were compared among groups.The disease-free survival(DFS)curve was plotted by Kaplan-Meier method.The factors influencing the DFS of en-dometrial cancer patients was analyzed by the univariate Log-rank test and multivariate Cox proportional hazards regression.[Results]Among 118 patients,85 cases(72.03％)had PTEN mutations,30 cases(25.42％)had P53 mutations,and 30 cases(25.42％)had dMMR.There were significant differences in muscle infiltration,lymphatic vascular infiltration,lymph node metastasis,and special pathological types among the three groups(all P＜0.05).The DSF of PTEN mutation group and non-mutation group were 72.02 months and 48.85 months,respectively(P＜0.001),the DFS of P53 non-mutation group and mutation group were 71.54 months and 43.21 months,re-spectively(P＜0.001),while there was no significant difference in DFS between dMMR group and non-dMMR group(P=0.450).There was a significant difference in DSF among PTEN mutation,P53 mutation,and dMMR groups(P＜0.001).Univariate analysis showed that preoperative CA125 value and clinical high-risk pathological factors(G3,muscle infiltration＞1/2,tumor size＞2 cm,vascular infiltration,lymph node metastasis,special pathological types)had a significant impact on DFS in patients with endometrial cancer(all P＜0.05).The Cox proportional hazards model showed that preoperative CA125 increase,vascular infiltration,and special pathologi-cal type were independent risk factors for DFS in endometrial cancer patients.[Conclusion]There are significant differences in the expression of PTEN,P53,and MMR among endometrial cancer patients with different clinico-pathological characteristics.The expression of PTEN,P53 and MMR might be used to evaluate the prognosis of patients.
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