铁死亡相关基因MTDH调控乳腺癌的研究进展
Research Progress on Ferroptosis-Related Gene MTDH in Regulation of Breast Cancer
郭梦杰 1南璐 1刘广进 1李元栋2
作者信息
- 1. 山西医科大学第一临床医学院,山西太原 030001
- 2. 山西医科大学第一医院,山西太原 030001
- 折叠
摘要
乳腺癌作为威胁女性健康的第一大癌,其治疗策略需要不断更新和完善.基因MTDH作为一个铁死亡过程的驱动基因,在乳腺癌中具有潜在的治疗价值.全文概述了MTDH在乳腺癌转移、耐药、免疫微环境、癌细胞干性中的作用以及其与铁死亡的相关性,显示其作为乳腺癌治疗的特异性靶标具有巨大潜力,但缺乏足够的临床研究数据支持.深入探索MTDH与乳腺癌及免疫的关系,有望找到新型治疗方法,克服目前乳腺癌治疗面临的转移及耐药难题,改善乳腺癌患者的治疗效果和预后.
Abstract
Breast cancer,as the leading cancer threatening women's health,requires constant updates and improvements in treatment strategies.MTDH,as a driver gene in ferroptosis,has po-tential therapeutic value in breast cancer.This paper reviews the role of MTDH in the metastasis and drug resistance of breast cancer,immune microenvironment,cancer stemness,and its cor-relation with ferroptosis.It demonstrates that MTDH,as a specific target for breast cancer treat-ment,has tremendous potential,but lacks sufficient clinical research data.Therefore,a thorough exploration of the relationship of MTDH with breast cancer and its immunity is expected to iden-tify novel treatment methods to overcome the drug resistance and improve the prognosis of breast cancer patients.
关键词
MTDH/乳腺癌/铁死亡/耐药性/免疫治疗Key words
MTDH/breast cancer/ferroptosis/drug resistance/immunotherapy引用本文复制引用
基金项目
山西省科技厅科技成果转化引导专项(202204021301066)
出版年
2024
NETL
NSTL
万方数据