Serum IL-6 Level Combined with CD4+/CD8+Ratio in Evaluate Severity and Predicting Recurrence of Gastric Cancer
[Objective]To analyze the clinical value of serum IL-6 level and CD4+/CD8+ratio in evaluate severity and predicting recurrence of gastric cancer.[Methods]A total of 120 patients with gastric cancer admitted from March 2015 to April 2018 were enrolled,and 60 healthy subjects were selected as controls.The serum IL-6 and CD4+/CD8+ratio of the two groups were compared;and their correlation with clinicopathological features of gastric cancer patients were analyzed.Patients were followed up for 5 years,the IL-6 level and CD4+/CD8+ratio were compared between patients with or without recurrence.The receiver operating characteristic(ROC)curve was used to analyze the value of IL-6 level combined with the ratio of CD4+/CD8+in predicting recurrence of gastric can-cer.[Results]Compared with healthy controls,the IL-6 level was significantly higher and the CD4+/CD8+ratio was lower in the gastric cancer patients(all P＜0.001).There were significant differences in IL-6 levels and CD4+/CD8+ratio among gastric cancer patients with different TNM stages,differenti-ation levels,and status of lymph node metastasis(all P＜0.001).The IL-6 levels in the recurrent group(n=13)were significantly higher,and the CD4+/CD8+ratio was significantly lower than those in the non-recurrent group(n=107)(all P＜0.001).ROC curve showed that the areas under the curve(AUC)of IL-6,CD4+/CD8+and combination of two indicators were 0.771,0.720 and 0.835,respec-tively(P＜0.001).[Conclusion]The high serum IL-6 level and the low CD4+/CD8+ratio are associated with the severity of gastric cancer patients;combined detection of both may serve as a monitoring indicator for predicting gastric cancer recurrence.
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