Advances on RGD Peptide Analogs for Diagnosis and Therapy of Malignant Melanoma
Malignant melanoma is a highly aggressive cancer characterized by high rates of metastasis and mortality.The prognosis of malignant melanoma is closely related to early diagnosis and accurate treat-ment.The abnormal expression of integrins occurs during the development and progression of malignant melanoma,which mediated tumor proliferation,invasion,and metastasis,and is closely associated with a poor prognosis.RGD peptide analogs,which utilize the arginine-glycine-aspartate(Arg-Gly-Asp)motif,can specifically bind to integrins,facilitating accurate diagnosis and targeted treatment of malignant tu-mors.This paper reviews the research advances on the sources and classification of RGD peptide analogs and their application in diagnosis and treatment of malignant melanoma.
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