Diagnostic Value of Serum Pepsinogen and Gastrin-17 in Early Gastric Cancer Patients with Positive Helicobacter Pylori Infection
[Objective]To explore the value of pepsinogen(PG)Ⅰ,PG Ⅱ,PG Ⅰ/PG Ⅱ ratio(PGR)and gastrin-17(G-17)in early diagnosis of gastric cancer in patients with Helicobacter pylori(Hp)infection.[Methods]One hundred and twenty-one patients with Hp infection were enrolled between January 2023 and April 2024.According to pathological results of gastroscopic biopsy,patients were divided into control group,precancerous lesion group and gastric cancer group.The changes of serum PG Ⅰ,PG Ⅱ,PGR and G-17 were compared among three groups,and their diagnostic value for gastric cancer was analyzed by re-ceiver operating characteristic(ROC)curve.[Results]Compared with control group,serum PG Ⅰ and PGR levels were decreased,while PG Ⅱ and G-17 levels were increased in gastric cancer group and precancer-ous lesion group(all P＜0.05).Compared with precancerous lesion group,serum PG Ⅰ and PGR levels were decreased,while G-17 level was increased in gastric cancer group(all P＜0.05).The area under ROC curve(AUC)of serum PG Ⅰ,PG Ⅱ,PGR,G-17 and the combination of 4 indicators in the diagnosis of gastric cancer were 0.866(95％CI:0.802～0.930),0.693(95％CI:0.582～0.804),0.847(95％CI:0.779～0.916),0.749(95％CI:0.654～0.845)and 0.955(95％CI:0.920～0.990),respectively.The AUC of combination of 4 indicators was greater than that of single index(P＜0.05).[Conclusion]Serum PG Ⅰ and PGR levels are decreased,while PGⅡ and G-17 levels are increased in Hp-positive patients with gastric cancer;the com-bined detection of 4 indicators has high value in early diagnosis of gastric cancer.
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