Influencing Factors of Survival Time After Brain Metastasis in Ninety-Four Paitents of Esophageal Carcinoma
[Objective]To summarize the influencing factors of survival after brain metastasis in esophageal cancer patients.[Methods]The clinical data of 12 760 esophageal carcinoma patients ad-mitted at the Zhejiang Cancer Hospital from 2012 to 2022 were analyzed retrospectively.The relation-ship between clinicopathological features and survival time after brain metastasis in patients with esophageal cancer was analyzed with Kaplan-Meier method,and the influencing factors on survival of patients were analyzed with multivariate Cox regression model.[Results]Among 12 760 patients with esophageal carcinoma,94 cases(0.74％)had brain metastases.The median interval between diagnosis of esophageal cancer and diagnosis of brain metastases was 0.69 years.Of the 94 cases with brain metastasis,84 died during follow-up,the median survival time after brain metastasis was 0.61 years with a 1-year survival rate of 37.3％.Univariate analysis showed that M stage,KPS score,single brain metastasis,extracranial metastasis,liver metastasis,primary treatment method,primary immunothera-py,brain metastasis surgery,brain metastasis radiotherapy,and brain metastasis chemotherapy were significantly associated with survival time after brain metastasis(all P＜0.05).Multivariate analysis showed that M staging(OR=1.757,95％CI:1.033～2.989)and extracranial metastasis(OR=1.741,95％CI:1.031～2.940)were independent risk factors of brain metastasis in esophageal cancer patients,while KPS score was a protective factor(OR=0.977,95％CI:0.965～0.989).[Conclusion]Esophageal cancer patient with low M stage,high KPS score at diagnosis of brain metastasis and no history of extracranial metastasis may achieve better survival after brain metastasis.
esophageal neoplasmsbrain metastasissurvival after brain metastasissurvivalinfluence factor
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