Effect of Postoperative Adjuvant Chemotherapy on Survival of Patients with Thoracic Esophageal Squamous Cell Carcinoma After Radical Surgery
[Objective]To investigate the effect of postoperative adjuvant chemotherapy on the survival of patients with thoracic esophageal squamous cell carcinoma after radical surgery.[Methods]A total of 395 patients with thoracic esophageal squamous cell carcinoma who under-went radical esophagectomy at Anyang Cancer Hospital from January 2014 to December 2021 were enrolled,including 192 patients receiving surgery alone and 203 cases receiving adjuvant chemotherapy after surgery.The overall survival(OS)and disease-free survival(DFS)were calcu-lated with Kaplan-Meier method,and compared between the two groups with Log-rank method.The OS and DFS of patients with stage Ⅲ or above and positive lymph nodes were analyzed.[Results]The 5-year DFS rates of surgery+chemotherapy group was longer than that of surgery alone group(47.6％vs 39.9％,P=0.004),while there was no significant difference in 5-year OS rates(60.1％vs 57.5％,P=0.113).Subgroup analysis showed that postoperative adjuvant chemotherapy significantly improved OS(P=0.038)and DFS(P＜0.001)in lymph nodes positive patients,and OS(P=0.016)and DFS(P＜0.001)in patients with stage Ⅲ and above.Multivariate logistic regression analysis showed that postoperative adjuvant chemotherapy was an independent prognostic factor for esophageal squamous cell carcinoma patients(OS:HR=1.878,95％CI:1.283～2.750,P=0.001;DFS:HR=1.986,95％CI:1.472～2.680,P＜0.001).[Conclusion]Postop-erative adjuvant chemotherapy can significantly improve the DFS of patients with thoracic esophageal squamous cell carcinoma after radical surgery,and can significantly improve the DFS and OS of patients with lymph nodes positive and stage Ⅲ and above.
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