Association of Gut Microbiota with the Malignant Degree of Pulmonary Nodules
[Objective]To investigate the association of gut microbiota with the malignant degree of pulmonary nodules.[Methods]A total of 54 patients with pulmonary nodules diagnosed in Beijing University of Chinese Medicine from January 1st to December 31st,2022 were enrolled,includ-ing 24 cases of low-risk lung nodules group,16 cases of high-risk lung nodules and 14 cases of lung cancer.The intestinal microbiota was examined by the 16S rDNA sequencing method,and data were analyzed with the SPSS 20.0 software.[Results]The Sob's index and Rank-abundance curves indicated that the gut microbiota of the three groups were rich and uniform,but the lung cancer group showed relatively lower diversity compared to the other two groups.The dominant bacterial genera in the gut microbiota were the same among three groups,but their relative abun-dances varied.The proportions of Faecalibacterium and Bifidobacterium decreased with the in-creased malignancy of lung nodules(all P＜0.05),while the proportions of Blautia and Bacteroides increased(all P＜0.05).The Kruskal-Wallis test revealed significant differences at the genus level of gut microbiota among the three groups(P＜0.05),and the Student's t-test for pairwise compar-isons showed that there were significant differences at the genus level of gut microbiota lung nod-ules with different malignancy degrees(P＜0.05).[Conclusion]Gut microbiota differ with varying degrees of lung nodule malignancy,which may serve as an objective biological basis to assist in the diagnosis of the nature of lung nodules.
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