Correlation of Inflammatory Markers and the Status of Tertiary Lymphoid Structures in Malignant Melanoma
[Objective]To explore the correlation between peripheral blood inflammatory markers,specifically C-reactive protein(CRP),lactate dehydrogenase(LDH),neutrophil lymphocyte ratio(NLR),and systemic inflammation response index(SIRI)and the status of tertiary lymphoid structures(TLS)in patients with malignant melanoma.[Methods]A total of 64 patients diagnosed with malignant melanoma for the first time and underwent surgical re-section at Nanjing Drum Tower Hospital,from February 2013 to December 2021.Preoperative blood routine test and biochemical examination were collected,including lymphocyte count,neutrophil count,monocyte count,CRP,and LDH.TLS status in tumors was analyzed using HE staining.Patients were divided into groups based on the presence of TLS in the tumor tissue and further categorized according to the presence of TLS in the center of the tumor.Receiver operating characteristic(ROC)curves were used to determine the optimal cutoff values for pre-dicting TLS status.Univariate and multivariate logistic regression analyses were conducted to identify independent predictors of TLS presence.[Results]Univariate logistic regression analysis showed that CRP,LDH,NLR,and SIRI levels were associated with the presence of TLS in the tumor(P＜0.100);Additionally,age,CRP,and LDH levels were linked to the presence of TLS in the center of the tumor(P＜0.100).Multivariate logistic regression anal-ysis revealed that LDH ≤ 205.5 U/L(OR=0.168,P=0.022)and SIRI ≤0.95(OR=0.235,P=0.039)were indepen-dent predictors for the presence of TLS in the tumor.Among patients with TLS in the tumor,CRP ≤ 2.7 mg/L(OR=0.208,P=0.021)and LDH＞177.5 U/L(OR=4.557,P=0.034)were identified as independent predictors for the pres-ence of TLS in the center of the tumor.[Conclusion]Peripheral blood inflammatory markers can be used to assess the tertiary lymphoid structure status in melanoma patients'tumor tissues.
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