The Value of Prognostic Nutritional Index in Prognostic Assess-ment of Breast Cancer Patients
[Objective]To explore the potential value of the prognostic nutritional index(PNI)in the prog-nostic assessment of breast cancer patients.[Methods]The clinical data of 165 breast cancer patients who received surgical treatment from June 2013 to June 2018 were analyzed retrospectively.The optimal cut-off value of PNI was determined by Receiver Operating Characteristic(ROC)curve analysis,and patients were divided into high and low PIN groups.The relationships of PNI with clinicopathological characteristics and prognosis of breast cancer patients were analyzed.[Results]ROC curve analysis i-dentified the optimal cut-off value of PNI as 50.29.PNI levels were significantly associated with age,lymph node metastasis,and tumor stage of breast cancer patients(all P＜0.05).Survival analysis revealed that the 5-year disease-free survival rate and 5-year overall survival rate in the high PNI group(50.29)were significantly higher than those in the low PNI group(＜50.29)(81.0％vs 55.0％,89.5％vs 76.7％,all P＜0.001).Univariate analysis showed that lymph node metastasis,tumor stage,histological grade and PNI level were significant factors affecting disease-free survival rate and overall survival rate of breast cancer patients.Cox multivariate analysis indicated that low PNI level(＜50.29)was an independent risk factor for disease-free survival(HR=0.544,95％CI:0.357～0.806,P=0.008)and overall survival(HR=0.489,95％CI:0.279～0.867,P=0.012)in breast cancer patients.[Conclusion]PNI,as an indicator comprehensively reflecting nutritional and immune status,may predict the prognosis of breast cancer pa-tients.
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