摘要
近年来,有机金属框架(MOFs)材料在各种抗菌领域得到广泛应用.过渡金属由于其生物相容性强、毒性弱,成本低而得到广泛研究.本文对三种典型的过渡金属MOFs,铜(Cu-MOF)、铁(Fe-MOF)和锆(Zr-MOF)的抗菌性能进行系统的比较.使用SEM和PXRD等仪器对MOFs的合成和微观结构进行验证和表征.对细菌(大肠杆菌)的试验结果表明,Cu-MOF、Fe-MOF和Zr-MOF的杀菌效果依次减弱.在相同的环境中,含有Cu-MOF的溶液中菌落数为0,表示了对大肠杆菌为100%的致死率,这一结果显著高于其他两组.但是暴露于光照后,Fe-MOF和Zr-MOF的抗菌性能分别提高了2.47%和73.56%,同样表现出优异的杀菌效果.
Abstract
Materials derived from metal-organic frameworks(MOFs)have found extensive applications in various antimicrobial uses in recent years.Transition metals have undergone extensive research due to their exceptional efficiency,low toxicity,and affordability.In this paper,three typical transition metal MOFs,copper(Cu-MOF),iron(Fe-MOF)and zirconium(Zr-MOF),are characterized in detail microscopically and their antimicrobial properties are systematically compared.The synthesis and microstructure of MOFs were validated using various instruments,such as SEM and PXRD.The investigation into bacterial(E.coli)test results revealed that the bactericidal effects of Cu-MOF,Fe-MOF,and Zr-MOF followed a descending order.Furthermore,the solution containing Cu-MOF displayed zero colonies in the same environment,demonstrating a 100%lethality against E.coli,a result significantly higher than the other two groups.Nevertheless,Fe-MOF and Zr-MOF exhibited an increase in antimicrobial properties of 2.47%and 73.56%,respectively,after exposure to light,both of which still demonstrated outstanding bactericidal effects.
基金项目
国家自然科学基金(52073311)
Guangdong Basic and Applied Basic Research Foundation(2021A1515012281)
NETL
NSTL
万方数据