In recent years,large-scale temporary isolation facilities were built or rebuilt due to the epidemic.When the epidemic ended,medical resources were left idle,operation crisis was found,and even abandoned.Based on the design concept of"combination of epidemic prevention and treatment",this paper took the new multifunctional isolation hotel as an example to analyze the characteristics of the new isolation hotel project.The intelligent design requirements and key points of"anti-epidemic combination"are proposed,which not only meet the operational requirements in peacetime,but also take into account the transformation requirements in case of epidemic,providing a reference for the overall design of intelligent system for similar projects in the future.