The therapeutic effect of〝Ke-Teng-Zi〞on histamine-induced mice with acute itching
To study the therapeutic effect of"Ke-Teng-Zi"(The seeds of Entada phaseoloides)extract on histamine-induced mice with acute itching,the successful histamine-induced acute itch mice were randomly divided into model group,"Ke-Teng-Zi"groups at 25.0,50.0,and 100.0 mg/kg dosage,and positive control group(diphenhydramine as positive drug,10.0 mg/kg).The results showed that the extract of"Ke-Teng-Zi"could reduce the number of scratches in histamine-induced mice with acute itching,significantly improve skin epidermal thickening,and relieve the infiltration of inflammatory cells and declined the number of mast cells.Furthermore,the extract of"Ke-Teng-Zi"could down-regulate the gene expression of HIR,TRPV1,IL-4,IL-6,IL-1β,IL-33,TNF-α,TSLP in skin and itch-related factor receptors in DRG,as well as decreasing the content of H1R,TSLP and IL-4 in the skin tissue.The extract of"Ke-Teng-Zi"could significantly alleviate the symptoms of mice with acute itching induced by histamine,and the mechanism may relate to the down-regulation of gene and protein expression of itching factors.
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