Preparation evaluation and transdermal absorption of nanoemulsion loading glabridin and nicotinamide
To improve the transdermal absorption properties of glabridin and nicotinamide,nano-emulsions(HPH-NE and HSSU-NE)were prepared by two high energy emulsification methods,and their morphology,particle size,Zeta potential,stability and skin permeability were investigated.The results showed that the two nanoemulsions were regular spherical without aggregation,their average particle size was respectively 51.60 nm and 42.98 nm,and the Zeta potential was-50.44 mV and-68.50 mV,respectively.HPH-NE and HSSU-NE had good stability under the conditions of centrifugation,storage and accelerated test.The nano-emulsion prepared by the two methods has better skin permeability than the ordinary emulsion,the average penetration rate of glabridin is increased by 3-5 times,and the average permeability of nicotinamide is increased by 1.6-2.6 times,which lays a solid foundation for the nano-preparation and cosmetics development of glabridin.
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