A strongly coupled electrophysiological simulation platform of sinoatrial node cells-fibroblasts is established by using the published electrophysiological data of sinoatrial node cells and fibroblasts.The simulation platform is used to conduct simulation experiments on the changes in the opening degree of ion channel under different levels of fibrosis,revealing the mechanism of sinoatrial node fibrosis.It is further proved that the calcium clock specificity change causes the sinoatrial node pathological fibrosis,which provides good support for the sinoatrial node pacemaker cells mechanism of calcium clock theory.
维普
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